The Science Behind 33B-α: What a Barrier-Boosting Peptide Really Does
When we talk about skincare, one ingredient that’s gaining serious attention is Activated Silk™ 33B-α. But what does it really do for your skin? Below, we dive into the science and why it’s more than just another “barrier peptide.”
What Is 33B-α, Scientifically Speaking?
Activated Silk™ 33B-α is a bioactive peptide derived from silk. Its INCI name is Fibroin Oligopeptide-1. What makes it special is how it signals your skin cells using natural biology. Rather than just covering the skin, 33B-α influences how your skin repairs itself. It helps your skin produce claudin-1, a protein that supports tight junctions between skin cells. These junctions are crucial: they keep moisture in and irritants out.
How 33B-α Strengthens Your Skin Barrier
It boosts barrier function, helping to lock in water and prevent irritation.
Because it is water-soluble, it can work in formulations where heavier ingredients (like petrolatum) don’t fit.
It helps your skin retain hydration naturally, without heavy occlusives, and supports a healthier, more resilient barrier.
Clinically Proven Benefits
In a study with human skin tissue, 33B-α was shown to:
Reduce transepidermal water loss (TEWL) in as little as 7 days
Lower redness and inflammation by helping tighten the barrier
Minimize the appearance of fine lines and wrinkles over several weeks, thanks to better hydration and skin structure
Why a Strong Barrier Means Better-Looking Skin
A healthy barrier is more than just “protected skin.” When your barrier is strong:
Your skin retains moisture better → less dryness and flaking
You experience less irritation and redness from daily stressors
Signs of aging like fine lines come in more slowly, because your skin is better able to heal itself
33B-α gives your skin the tools it needs to stay strong naturally.
Safety & Sustainability: Built Into the Biology
This peptide is non-toxic, non-sensitizing, and safe for topical use even around the eyes
It’s also biodegradable and upcycled, made from renewable silk protein, which supports sustainability and reduces waste.
Because its production doesn’t rely on fossil fuels or synthetic petrochemicals, 33B-α supports a more environmentally responsible beauty industry.
How 33B-α Fits Into Your Skincare Routine
Use it in a lightweight serum or leave-on formula to boost your barrier daily
It pairs well with other actives or post-procedure ingredients for enhanced barrier repair
You can also find it in gentle cleansers or rinse-off formulas because it’s water-soluble, it stays effective even after rinsing
The Bottom Line
Activated Silk™ 33B-α is not just another peptide. It’s a next-generation, science-backed solution for strong, hydrated, and resilient skin. Rather than masking damage, it helps your skin rebuild itself.
Ready to strengthen your skin barrier for the long term? Order Now or Book your consultation at Core Aesthetics to explore how 33B-α can fit into your personalized skincare strategy.
For questions about silk peptide, email our team at wellness@prestonspharmacy.com and we’ll be happy to help.
