Can LDN Help You Sleep Better? Here’s What the Research Says

If you’ve been struggling with restless nights, tossing and turning despite trying every trick in the book—melatonin, magnesium, sleep hygiene—you’re not alone. And you might be surprised to learn that relief could come from a therapy originally developed for entirely different conditions.

Low-Dose Naltrexone (LDN), a medication best known for supporting immune regulation and reducing inflammation, is gaining attention for another reason: better sleep.

Why LDN Might Improve Sleep

LDN makes your body create more natural "feel-good" chemicals called endorphins. These endorphins lift your mood, ease pain, help control your immune system, which may explain why so many people report:

• Falling asleep more easily

• Fewer night wakings

• Deeper, more restorative sleep

What Does the Research Say?

While large-scale studies are still ongoing, early evidence and patient testimonials suggest that LDN may positively impact sleep by:

• Reducing systemic inflammation that disrupts normal sleep rhythms

• Calming overactive immune responses, which may be linked to conditions like insomnia and fibromyalgia

• Enhancing mood and reducing anxiety, two common sleep disruptors

In one survey of LDN users with autoimmune conditions, over 60% reported improved sleep within the first 8 weeks of use.

A Personalized, Gentle Option

If poor sleep is affecting your quality of life—and nothing else has helped—LDN could be worth a conversation with your provider.

At Preston’s Pharmacy, we’re here to help you explore your options with care, clarity, and a commitment to personalized wellness. Our pharmacists work closely with you and your healthcare team to create a treatment plan that supports your sleep, and your whole health.

Please call us on (571) 341-8787 or Email us at info@prestonscompounding.com