LDN + Thyroid: Why Some Patients Still Struggle on T4 Alone

Still not feeling like yourself—even on thyroid meds? You’re not alone. For many people with Hashimoto’s or other autoimmune thyroid conditions, traditional T4 therapy (like levothyroxine) doesn’t fully resolve lingering symptoms like fatigue, brain fog, or weight changes. That’s because thyroid issues aren’t just hormonal—they’re often inflammatory too.

Where Inflammation Comes In

Hashimoto’s thyroiditis is, at its core, an autoimmune condition. Even when T4 levels are “normal,” your immune system may still be firing against your thyroid. This ongoing inflammation can affect how your body uses thyroid hormone—and how you feel day-to-day.

LDN: A New Tool for Thyroid Wellness

Low-Dose Naltrexone (LDN) is gaining attention as a gentle way to calm immune overactivity without suppressing it entirely. Unlike typical immune-modulating drugs, LDN helps regulate the immune response—potentially reducing flare-ups and improving energy, mood, and mental clarity.

Patients on LDN often report:

• Fewer thyroid-related flares

• More stable mood and sleep

• Less joint and muscle pain

• A gradual reduction in thyroid antibodies (in some cases)

Why LDN + T4 Makes Sense

T4-only medications support hormone levels. LDN addresses what’s happening behind the scenes—your immune system. For some, this combo leads to the first real progress they’ve seen in years.

“I was taking my meds like clockwork, but still exhausted. LDN gave me a new level of calm and clarity I didn’t expect.” —Patient at Preston’s

Compounded LDN, Personalized to You

At Preston’s Pharmacy, we work with your provider to customize LDN in the dose that best suits your needs. Whether you’re newly diagnosed or managing thyroid symptoms long-term, we’re here to support your journey with clarity, compassion, and science-backed care. Please call us on (571) 341-8787 or Email at info@prestonscompounding.com