Say Goodbye to Irritated Skin: How 33B-α Calms and Protects
Irritated skin can feel like your barrier is failing tight, red, and uncomfortable. What if there was an ingredient that actually helps your skin heal itself from within? That’s where Activated Silk™ 33B-α comes in, a powerful peptide that calms inflammation and reinforces your skin’s defense system.
What Is 33B-α, and Why It Matters for Irritation
33B-α (INCI: Fibroin Oligopeptide-1) is a bioactive peptide derived from silk. Unlike heavy creams or occlusives that simply cover irritation, 33B-α works on a cellular level. It signals your skin to produce claudin-1, a protein that helps skin cells stick together and form a stronger, tighter barrier.
When your skin barrier is healthy, it’s better able to lock in moisture and keep out irritants, which reduces redness, sensitivity, and inflammation.
How 33B-α Soothes Redness and Inflammation
Reduces Transepidermal Water Loss (TEWL): Clinical studies show a significant drop in TEWL in just 7 days of using 33B-α meaning less dryness and a more resilient barrier.
Calms Redness Quickly: Users in trials saw a noticeable reduction in redness in as little as one week.
Gentle Yet Effective: 33B-α is non-toxic, non-irritating, and safe even for sensitive areas like around the eyes.
Long-Term Protection: Building a Stronger Barrier
Irritated skin often comes from a weakened barrier. Over time, a compromised barrier can cause chronic sensitivity or reactive skin. By using 33B-α consistently, you help your skin:
Strengthen its barrier architecture through claudin-1 support
Maintain hydration naturally, without heavy occlusives
Recover and stay calm even when exposed to stressors, pollution, or harsh ingredients
Sustainable Skin Health: From Nature to You
What makes 33B-α even more remarkable is how it’s made. This peptide is derived from upcycled silk, turning silk farm by-products into a high-performance ingredient. It’s biodegradable, renewably sourced, and supports a circular economy.
Plus, its water-soluble nature means it can be used in lightweight formulas even in rinse-off products like cleansers without losing efficacy.
Who Benefits Most from 33B-α?
This peptide is a smart addition to any skincare routine, but it’s especially helpful for:
People dealing with sensitivity, redness, or frequent irritation
Those with dry or reactive skin
Anyone looking for anti-aging support without heavy “barrier-fixing” creams
How to Use 33B-α for Calm and Protection
Apply a 33B-α serum or lightweight moisturizer daily to soothe and strengthen your barrier.
Layer it under retinoids or exfoliants to reduce their irritation.
Use it in post-procedure routines to help your skin recover faster and look healthier.
Ready to calm and protect your skin? Order now through our website or email our team at wellness@prestonspharmacy.com to learn more about 33B-α and how it can help your skin thrive.
