LDN for Crohn’s or Ulcerative Colitis: Can It Help When Biologics Don’t?

If you’re living with Crohn’s disease or Ulcerative Colitis (UC), you know how exhausting the cycle of flare-ups, fatigue, and gut discomfort can be. While biologics and immunosuppressants help some, many patients are still searching for relief—without the heavy side effects.

Low-Dose Naltrexone (LDN) could be the missing piece.

What the Research Says

Early studies and patient reports suggest that LDN may:

• Reduce intestinal inflammation

• Decrease frequency and severity of flare-ups

• Promote mucosal healing

• Improve quality of life in IBD patients

• Have minimal to no side effects

In fact, some patients see improvement when biologics or steroids stop working—or when side effects become intolerable.

How LDN Works in IBD

LDN works by:

• Modulating the immune system, not suppressing it

• Reducing pro-inflammatory cytokines

• Supporting the body’s natural repair pathways in the gut lining

For many, this means less pain, better digestion, and more energy.

Why Compounded LDN?

At Preston’s Pharmacy, we specialize in custom-compounded LDN. That means:

• The dose is tailored to you

• Your provider can adjust it as needed

• You get consistent, high-quality formulation

We work with your care team and offer guidance on dosing and symptom tracking.

Start Small, Feel the Shift

Sometimes less is more. Low-dose naltrexone may offer relief without the intensity of traditional therapies. We’re here to help you explore your options—reach out to Preston’s Pharmacy today. Call us at (571) 341-8787 or email us at info@prestonscompounding.com.